Immunogenetics of Type 1 Diabetes

Immunogenetics of type 1 diabetes.

The T-cell mediated autoimmune process that destroys pancreatic beta cells in type 1 diabetes (T1D) is a complex phenotype influenced by multiple genetic and environmental factors. Human leukocyte antigen (HLA) accounts for about half of the genetic susceptibility, through a large variety of protective and predisposing haplotypes. Other important loci associated with T1D, with much smaller effe...

Immunogenetics of type 1 diabetes mellitus Azza

Introduction Type 1 diabetes mellitus (T1D) is one of the most common autoimmune diseases with several million people already affected around the globe. It can occur at any age, but is most commonly diagnosed from infancy to the late thirties. It is characterized by an absolute loss of insulin secretion, and results from an autoimmune process that destroys insulinproducing ß cells within the pa...

Immunogenetics of Type 1 Diabetes in Man

Immunogenetics of Type 1 Diabetes Rajni

Immunogenetics of type 1 diabetes: A comprehensive review.

Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing beta cells in the pancreas. Prevention of T1D will require the ability to detect and modulate the autoimmune process before the clinical onset of disease. Genetic screening is a logical first step in identification of future patients to test prevention strategies. Susceptibility to T1D includes a strong genetic c...